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References to Publications describing the use of the MicroSource Screening Collections.

Spectrum Collection
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation: J. Clinical Investigatrion.:doi:10.1172/JCI39199 (2009)

Identification of antifungal compounds active against candida albicans using an improved high-throughput Caenorhabditis elegans assay: PloS ONE 4: e6044. DOI:10.1371/journal.pone.0006044 (2009)

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects: Chemistry & Biology 16: 712 (2009)

A Novel Flow Cytometric High Throughput Assay for a Systematic Study on Molecular Mechanisms Underlying T Cell Receptor-Mediated Integrin Activation: PloS ONE 4: e7025. DOI:10.1371/journal.pone.0007025 (2009)

High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias: J Lipid Research 49: 230-244 (2008)

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen: PloS Genetics 4: e1000005. DOI:10.1371/journal.pgen.1000005

Researchers demonstrate activity of mebendazole in metastatic melanoma: www.physorg.com, pdf137325546.pdf [7 Aug, 2008]

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism: Academic Thesis (2008): http://ymtdl.med.yale.edu/ theses/available/etd-11212008-111938/restricted/BenBowlingthesis08.pdf

Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture: Investigative Ophthalmology and Visual Science 48:412-421 (2007)

Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase: Journal of Endocrinology 194: 569-578 (2007)

Mefloquine, an antimalarial drug with antiprion activity in vitro, lacks activity in vivo: J Virology 80: 1044-1046 (2006)

Searching for new antimalarial therapeutics amongst known drugs: Chemical Biology and Drug Design 67: 409–416 (2006).

A systematic review of prion therapeutics in experimental models: Brain 129: 2241-2265 (2006)

A novel small-molecule inhibitor of protein kinase c blocks transformed growth of non–small-cell lung cancer cells: Cancer Research 66: 1767-1774 (2006)

Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking: J Biol Chem 281: 5877-5884 (2006)

Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat AS, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH Chemical Biology and Drug Design. 67: 355-363 (2006)

Finding new tricks for old drugs: an efficient route for public-sector drug discovery: Nature Reviews-Drug Discovery 4: 1005-1014 (2005)

Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations: Mol Pharmacology 68:1736-1746 (2005)

New inhibitors of Scrapie-associated prion protein formation in a library of 2,000 drugs and natural products: J Virology 77: 10288–10294 (2003)

Development, validation, and screening for inhibitors of severe acute respiratory syndrome coronavirus in a luminescence-based high throughput screen: www.southernresearch.org/pdf/SARS-Poster-9-2-05.pdf

US Drug Collection
Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5: J Biomol Screen 15: 488-497 (2010 )

Screening for inhibitors of the SOD1 gene promoter: Pyrimethamine does not reduce SOD1 levels in cell and animal models : Neuroscience Letters 482: 188-192 (2010) [doi:10.1016/j.neulet.2010.07.020]

Actinomycin D identified as an inhibitor of Discoidin Domain Receptor 2 interaction with collagen through an insect cell based screening of a drug compound library: Biol Pharm Bull 32: 136-141 (2009)

Natural Products Collection
Two Seven-Transmembrane Domain MILDEW RESISTANCE LOCUS O Proteins Cofunction in Arabidopsis Root Thigmomorphogenesis: The Plant Cell 21: 1972-1991 (2009)

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3): eCAM 2: 209-215 (2005)

Killer Collection
Searching for new antimalarial therapeutics amongst known drugs: Chemical Biology and Drug Design 67: 409–416 (2006).

International Drug Collection
Current references coming soon.