|

References to Publications describing the use of the MicroSource Screening Collections.
Spectrum Collection
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation:
J. Clinical Investigatrion.:doi:10.1172/JCI39199 (2009)
Identification of antifungal compounds active against candida albicans using an improved high-throughput Caenorhabditis elegans assay:
PloS ONE 4: e6044. DOI:10.1371/journal.pone.0006044 (2009)
Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects:
Chemistry & Biology 16: 712 (2009)
A Novel Flow Cytometric High Throughput Assay for a Systematic Study on Molecular Mechanisms Underlying T Cell Receptor-Mediated Integrin Activation:
PloS ONE 4: e7025. DOI:10.1371/journal.pone.0007025 (2009)
High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias:
J Lipid Research 49: 230-244 (2008)
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen:
PloS Genetics 4: e1000005. DOI:10.1371/journal.pgen.1000005
Researchers demonstrate activity of mebendazole in metastatic melanoma:
www.physorg.com, pdf137325546.pdf [7 Aug, 2008]
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism:
Academic Thesis (2008): http://ymtdl.med.yale.edu/
theses/available/etd-11212008-111938/restricted/BenBowlingthesis08.pdf
Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture:
Investigative Ophthalmology and Visual Science 48:412-421 (2007)
Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase:
Journal of Endocrinology 194: 569-578 (2007)
Mefloquine, an antimalarial drug with antiprion activity in vitro, lacks activity in vivo:
J Virology 80: 1044-1046 (2006)
Searching for new antimalarial therapeutics amongst known drugs:
Chemical Biology and Drug Design 67: 409–416 (2006).
A systematic review of prion therapeutics in experimental models:
Brain 129: 2241-2265 (2006)
A novel small-molecule inhibitor of protein kinase c blocks transformed growth of non–small-cell lung cancer cells:
Cancer Research 66: 1767-1774 (2006)
Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking:
J Biol Chem 281: 5877-5884 (2006)
Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat AS, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH
Chemical Biology and Drug Design. 67: 355-363 (2006)
Finding new tricks for old drugs: an efficient route for public-sector drug discovery:
Nature Reviews-Drug Discovery 4: 1005-1014 (2005)
Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations:
Mol Pharmacology 68:1736-1746 (2005)
New inhibitors of Scrapie-associated prion protein formation in a library of 2,000 drugs and natural products:
J Virology 77: 10288–10294 (2003)
Development, validation, and screening for inhibitors of severe acute respiratory syndrome coronavirus in a luminescence-based high throughput screen:
www.southernresearch.org/pdf/SARS-Poster-9-2-05.pdf
US Drug Collection
Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5:
J Biomol Screen 15: 488-497 (2010
)
Screening for inhibitors of the SOD1 gene promoter: Pyrimethamine does not reduce SOD1 levels in cell and animal models :
Neuroscience Letters 482: 188-192 (2010) [doi:10.1016/j.neulet.2010.07.020]
Actinomycin D identified as an inhibitor of Discoidin Domain Receptor 2 interaction with collagen through an insect cell based screening of a drug compound library:
Biol Pharm Bull 32: 136-141 (2009)
Natural Products Collection
Two Seven-Transmembrane Domain MILDEW RESISTANCE
LOCUS O Proteins Cofunction in Arabidopsis Root Thigmomorphogenesis:
The Plant Cell 21: 1972-1991 (2009)
Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3):
eCAM 2: 209-215 (2005)
Killer Collection
Searching for new antimalarial therapeutics amongst known drugs:
Chemical Biology and Drug Design 67: 409–416 (2006).
International Drug Collection
Current references coming soon.
|